ANALYTICS
Analytical services from discovery up to GMP production
Our capabilities
At Exothera, our analytical services cover DNA, RNA and LNPs analysis from discovery to preclinical and clinical phases and include quality control during GMP manufacturing.
We offer analytical capabilities during the development and manufacture of our solutions, and also offer this as a separate service.
We can help you:
- develop new analytical methods or adapt specific analytical methods to your product,
- perform routine analysis of R&D samples based on our standard analytical qualified methods catalog,
- analyze GMP samples based on our QC’s validated method catalog,
- validate new analytical methods or specific methods adapted to your product.

Our testing methods
Drug substance |
Analyte |
Method |
mRNA identity | Nanopore sequencing |
mRNA content | Ribogreen spectrofluorimetry |
mRNA integrity | FA Cap electroph |
Capping efficiency | HPLC-UV |
dsRNA | ELISA |
In vitro expression | HEK Transfection/ELISA |
Residual proteins | µBCA |
Residual pDNA | qPCR |
Sterility | Compendial |
Bioburden | Compendial |
Endotoxins | Compendial |
Appearance | Compendial |
pH | Compendial |
Drug product |
Analyte |
Method |
Encapsulation yield | Ribogreen spectropfluorimetry |
LNP size/PDI | Dynamic Light Scattering |
Lipid content | HPLC-CAD |
Lipid degradation | HPLC-CAD |
Cytotoxicity | CKK8 |
pH | Potentiometry |
Osmolality | Freezing-point depression |
Endotoxins | LAL |
Sterility | Compendial |
Bioburden | Compendial |
Endotoxins | Compendial |
Appearance | Compendial |
pH | Compendial |
Our capabilities
At Exothera, our analytical services cover DNA, RNA and LNPs analysis from discovery to preclinical and clinical phases and include quality control during GMP manufacturing.
We offer analytical capabilities during the development and manufacture of our solutions, and also offer this as a separate service.
We can help you:
- develop new analytical methods or adapt specific analytical methods to your product,
- perform routine analysis of R&D samples based on our standard analytical qualified methods catalog,
- analyze GMP samples based on our QC’s validated method catalog,
- validate new analytical methods or specific methods adapted to your product.

Our testing methods
Drug substance |
Analyte |
Method |
mRNA identity | Nanopore sequencing |
mRNA content | Ribogreen spectrofluorimetry |
mRNA integrity | FA Cap electroph |
Capping efficiency | HPLC-UV |
dsRNA | ELISA |
In vitro expression | HEK Transfection/ELISA |
Residual proteins | µBCA |
Residual pDNA | qPCR |
Sterility | Compendial |
Bioburden | Compendial |
Endotoxins | Compendial |
Appearance | Compendial |
pH | Compendial |
Drug product |
Analyte |
Method |
Encapsulation yield | Ribogreen spectropfluorimetry |
LNP size/PDI | Dynamic Light Scattering |
Lipid content | HPLC-CAD |
Lipid degradation | HPLC-CAD |
Cytotoxicity | CKK8 |
pH | Potentiometry |
Osmolality | Freezing-point depression |
Endotoxins | LAL |
Sterility | Compendial |
Bioburden | Compendial |
Endotoxins | Compendial |
Appearance | Compendial |
pH | Compendial |